Scientists found a way to investigate human susceptibility to infectious disease


The new acquired knowledge also points to possible avenues to protect against pathogens, like Salmonella or Ebola , whose entry into host cells is regulated by cholesterol. So, the statin taken to lower risk of hearth attack or stroke may providing protection against a whole host of infectious diseases, including typhoid fever, chlamydia, and malaria. “This is just the first step,” said Dennis C. Ko, M.D., Ph.D., senior author of the study and assistant professor of Molecular Genetics and Microbiology at Duke University School of Medicine.

Salmonella (marked red) invading immune cells

“What’s so exciting is that our study provides a blueprint for combining different techniques for understanding why some people are more susceptible to disease than others, and what can be done about it,.” he also revealed. Researchers performed experiments in fishes and mices and are prepared to conduct experiments in humans already taking cholesterol-lowering drugs. “Our cell-based human genetic approach is a way for us to connect cell biology to human disease,” said Ko. The study was published in the Proceedings of the National Academy of Sciences giving a point of depart for other researchers to make various tests which could conclude in clinical procedures.


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