In a recent clinical study, a regimen of combined oral and topical corticosteroids were effectively used. In some cases of CRS, severe inflammation leads to growths in the nose and the sinuses called polyps which can completely fill the nasal cavity–completely blocking nasal breathing and one’s sense of smell. . More than 60 patients with severe CRS with nasal polyps participated in the clinical study. It was demonstrated that a large fraction of patients may experience well-controlled symptoms, and therefore avoid surgery. The present study suggests a new approach in the management of chronic rhinosinusitis. Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common inflammatory disorder, affecting about 4% of the population worldwide and strongly impacts the quality of life of affected patients.
This study was the first to demonstrate that even in patients with severe CRS with nasal polyps, a large fraction of patients may experience well-controlled symptoms. Co-authors of the study included Madison V. Epperson, BA, a medical student at the UC College of Medicine; Katie M. Phillips, MD, Department of Otolaryngology–Head and Neck Surgery, Stanford University; David S. Caradonna, MD, DMD, Department of Otolaryngology, Harvard Medical School and the Division of Otolaryngology, Beth Israel Deaconess Medical Center; and Stacey T. Gray, MD, Department of Otolaryngology, Harvard Medical School and the Department of Otolaryngology, Massachusetts Eye and Ear Infirmary.