It seems they identified two unique pathways that could lead to the development of “new, more targeted cancer therapies.” One of these ncRNA genes, named GUARDIN, is a molecule that helps to stabilize a particular protein involved in the DNA repair process.”We discovered the protective mechanisms of GUARDIN were twofold,” lead Investigator Professor Xudong Zhang from the University of Newcastle said. In fact researchers found that reducing GUARDIN actually made cancer cells become more vulnerable to drug treatments. Depleting GUARDIN significantly enhanced the death of cancer cells caused by DNA damaging drugs,” co-author, Dr Jin explained.
On other way, based on discovery that cancer cells use a process called glycolysis to produce energy, researchers influenced cancer cells comportment. With many times more noncoding genes than coding genes, the findings have unlocked new avenues for research potential that could lead to a substantial increase of advanced and targeted treatment methods. The new pathways expand the horizon for cancer research. “There are currently no treatments anywhere in the world that target ncRNA, so this research presents promising potential for further studies and collaboration with pharmaceutical companies to design deliverable treatments that target these particular molecules,” Professor Zhang said.