. The vaccine needs to be given four times : once a month for three months and then a fourth dose 18 months later. The benefits fall off significantly without the crucial fourth dose. The pilot vaccination program will involve more than 750,000 children aged between five and 17 months. Despite huge progress, there are still 212 million new cases of malaria each year and 429,000 deaths and Africa is the hardest hit. Malaria causes symptoms that typically include fever, feeling tired, vomiting, and headaches. In severe cases it can cause yellow skin, seizures, coma or death. Symptoms usually begin ten to fifteen days after being bitten. If not properly treated, people may have recurrences of the disease months later.