The experimental coronavirus vaccine study of AstraZeneca was put on hold in America

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Pharmaceutical company AstraZeneca will put an experimental coronavirus vaccine study on hold in America after a participant in the United Kingdom faced an apparent serious adverse reaction. The pause is “a routine action which has to happen whenever there is a potentially unexplained illness in one of the trials. A suspected serious adverse reaction includes symptoms that require hospitalization, life-threatening illness and even death. It was also not immediately clear which clinical trial the adverse reaction occurred in. A Phase 1/2 study published in July reported about 60% of 1,000 participants on the vaccine experienced side effects. The AstraZeneca vaccine, known as AZD1222, was invented by the University of Oxford and an associated company, Vaccitech.

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The monoclonal antibodies are derived from the convalescent plasma of COVID-19 patients. AstraZeneca only began its Phase 3 trial in the U.S. in late August. The U.S. trial is currently taking place at 62 sites across the country. Phase 2/3 trials were previously started in the U.K., Brazil, and South Africa. The Oxford vaccine uses a type of virus called an adenovirus to teach the immune system how to make antibodies to attack the coronavirus’ so-called spike protein. It’s that spike protein that allows the virus to infect human cells.