“It’s exciting to think that metabolic therapy may now be poised to take its place beside aspirin and cholesterol- and blood pressure-lowering therapies for preventing stroke in non-diabetic patients,” Dr. Silvio Inzucchi, from Yale University said. But taking the drug could favorise some bones fractures. Patients who took the drug also showed weight gain and edema. The positive results were presented at the International Stroke Conference 2016 in Los Angeles and published in the New England Journal of Medicine.The drug is intented to be used especially for prevention against secondary strokes to the patients who had one. Pioglitazone, commercially known as Actos, was the tenth-best selling drug in the U.S. in 2008, with sales exceeding $2.4 billion. It does decrease blood sugar levels.