Researchers are currently investigating the non-steroidal anti-inflammatory drug’s (NSAID) effects on cancer in four clinical trials. “It’s still somewhat surprising that there is still so much we don’t understand about how many of the standard drugs we use every day, like diclofenac, work,” Dr. Pan Pantziarka, a researcher at the Anticancer Fund (a private foundation providing research-based information on cancer therapies) said in a press release.
Usually, Diclofenac is taken or applied to reduce inflammation and as an analgesic reducing pain in certain conditions. It is available as a generic drug in a number of formulations. Inflammatory disorders may include musculoskeletal complaints, especially arthritis, rheumatoid arthritis, polymyositis, dermatomyositis, osteoarthritis, dental pain, TMJ pain, spondylarthritis, ankylosing spondylitis, gout attacks, and pain management in cases of kidney stones and gallstones.
On the other side, the European Medicines Agency stated that diclofenac benefits continue to outweigh its risks, but stresses that certain patients should be cautious. They say Patients who have certain cardiovascular risk factors such as hypertension, hypercholesterolemia, diabetes mellitus or smoking, should use the drug diclofenac only after careful evaluation.