If one or many such manifestations occur, immediate medical attention is required. Of course, the incriminated product will not be longer used by the affected people. Some producers name brands were enumerated including Proactiv, Neutrogena, MaxClarity, Oxy, Ambi, Aveeno and Clean & Clear were enumerated as containing the potential allergen substances. A dangerous reaction is possible within minutes of using a product, or up to a day after it was applied. Fortunately, only 131 allergic accidents were registered during 45 years, possibly others were not reported. However, 44 percent of the cases required the person to be hospitalized. Other common reactions using pharmaceutical products in acne treatments are burning, dryness, itching, peeling, redness and slight swelling in the area where the product is applied. FDA recommended as a general preventive comportment that consumers apply a small amount to a limited area for three days when a new product is tested.