Spencer’s first film role was in Quel fantasma di mio maitro, an Italian comedy shot in 1949 and released in 1950. He worked in over 20 films with his partner Terence Hill: Hannibal, God Forgives… I Don’t, Ace High, Boot Hill, They Call Me Trinity, Blackie the Pirate, Trinity is still my name, All the Way, Boys, Two Missionaries, Crime Busters, Double Trouble, Miami Supercops, Everyrhing Happens To Me, Bomber and more. He was also well known for his role in Detective Extralarge TV series. Spencer wrote the complete or partial screenplay for some of his movies. Spencer stated: “In my life, I’ve done everything. There are only three things I haven’t been – a ballet dancer, a jockey and a politician.” He tried later without success to enter politics for the Forza Italia party.